According to the World Health Organisation, at least 2.2 billion people globally have vision impairments or blindness.
Some lipophilic bioactives are effective at preventing common ocular diseases. Among them, β-carotene has gained much attention for its high provitamin A activity, and lutein and zeaxanthin are capable of preventing macular degeneration and cataracts, and have a filtering effect on harmful blue light. Also, fish oil is a rich source of omega-3 fatty acids and is effective in the treatment of dry eye disease and AMD.
But the inherent chemical reactivities of these lipophilic compounds make them sensitive to oxygen, light, and heat, which greatly limit their applications.
Microencapsulation is a feasible approach to preserve these bioactive compounds and there are many techniques available. Two-fluid nozzle spray drying (SD) and freeze-drying (FD) have been widely applied in the microencapsulation of lipophilic bioactives while microfluidic-jet spray drying (MFJSD) is a relatively novel technique that produces monodisperse microparticles.
At present, the studies on bioactive encapsulation by MFJSD are quite limited, and none of them have reported on the co-encapsulation of carotenoids and fish oil, according to the authors of the current study.
This study therefore aimed to understand the effects of the three processes on the properties, storage stability, and digestibility of microcapsules containing carotenoids (β-carotene, lutein, zeaxanthin, from DSM Nutritional Products), and fish oil (Incromega TG3322, from Croda International).
Study: Microfluidic-jet spray drying superior for eye health ingredient microencapsulation - NutraIngredients.com
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